logo „JOHN ATANASOFF“ CENTER
FOR BIO AND NANO PHOTONICS, JAC BNP

JAC BNP is a nonprofit organization for public benefit founded by three institutions - Sofia University "St. Kliment Ohridski" (the largest and the best research and educational institution in Bulgaria, it is the only Bulgarian university included in the prestigious QS World University Ranking) , the Institute of Bio and Nano Photonics (nonprofit organization for public benefit established by world well-established scientists which are leaders in the JAC BNP research areas, whose vision is to contribute to the reform and development of the research environment in Bulgaria to the level of excellence); Center for Innovative Technologies - nonprofit organization for public benefit established by experts and entrepreneurs with experience in the interdisciplinary R&D, and technology transfer areas ). The real need for active participation of established world scientists in national research institutions has been taken into account. For this purpose, in 2016 the "Institute for Bio and Nano Photonics" was founded and most of its founders were prominent scientists of Bulgarian origin. The first step of the association was the appointment of leading world researchers at the Association for preparation and conducting of scientific research in compliance with the visions of the National Innovation Strategy for Smart Specialisation 2014-2020, as well as Horizon 2020. The research to be performed in pursuit of JAC BNP’s grand goals will be organized in 8 major areas of interdisciplinary research (A-H). The main scientific direction and specific projects and tasks of each research area will be coordinated by at least two world-leading scholars and one of them will be from a well-established research intuition abroad.

The Centre includes 67 researchers, 5 entrepreneurs with strong experience and knowledge in the translation of research knowledge to new technologies and start-up companies. There are also 5 specialists in project management able to provide legal advice, finance management, accounting and building expertise. The researchers directly involved in the research program of the Centre have published 984 papers in peer-reviewed refereed journals during the program term 2011-2015 and have been cited >9833 times during the same period, while the total number of citations exceeds >65,000. The researchers in the team have published in top-ranked journals, including numerous publications in Nature and Science, as well as in other renowned journals. The number of publications in Nature and Science over the period 2011-2015 is 27. Over the program evaluation period 2011-2015, the participants in the project team also led successfully research and investment programs with a total funding exceeding 200 million euros (400 million BGN). Out of these 25 million euros (50 million BGN) have been in donor research programs. The basic center structure, research plans, projects and planned operation is fully in line with the objective of building a research infrastructure responding to the challenges of science and technology of the 21st century.

Building

Goals

1

Accomplishment of independent fundamental scientific research, industrial research activities or experimental development and/or dissemination of the results in wide range, via education, publications and knowledge transfer;

2

Cooperation of the scientific workers and researchers, needed for creation of scientific research and educational environment in the country, where scientific knowledge and technologies are spreading freely;

3

Partnership in realization of regional-innovative projects and encouragement of conducting scientific research activities;

4

Increase of the role of the scientific research activities and innovative technologies in the industry;

5

Partnership in the international scientific experience exchange;

6

International practice exchange contribution in the scientific research activities and innovative technologies, and also in the industry and household and throughout the country;

7

Support for the professional and personal realization of scientific workers and researchers within the country;

8

Participation in accomplishment of different projects in the area of the fundamental scientific and industrial research activities or experimental development.

Areas of Research:

Bio and Nano Photonics is an emerging field of research located at a strategic crossroad where life science, physics, chemistry, engineering and nanotechnology meet. These five closely interacting areas provide a relevant multi-disciplinary background, as well as timely motivations for the development of designers light tools at ultimate time and space scales. Exploratory and fundamental investigations related to extreme laser light and matter interactions in organic, inorganic and in organic-inorganic hybrid systems, enabled by recent technological breakthroughs, are now increasingly at the focus of bio and nano photonics leading to a large number of discoveries. The Center works on 8 thematic areas:
List of research areas. A (DNA repair) B (Coherent X-ray Design and 5D Imaging) C (Light Diagnostics and Imaging of living matter) D (Laser-assisted functionalization and assessment of biomaterials) E (Laser Medical and Biological Reasearch) F (Photobiomodulation) G (Biosensing) H (Ultrafast Biophotonics and Life Science)

Labs

Research Labs

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    Molecular Cell Biology Lab
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    DNA Рepair, Genomic Сtability, Cancer and Genetic Deceases Labs
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    Coherent X-ray Labs
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    Biomedical Laser Application Lab
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    Raman Imaging Lab
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    Biosensing Lab
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    Opto-Acoustic Imaging and Light Diagnostics Lab
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    Femto-pico-nano-second Dynamics Lab
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    Laser Development Lab

Utility Labs

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    Chemical Preparation Lab
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    Instrument Fabrication Facility
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    Electronics Facility
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    Computing Facility

Projects

METAFAST

METAsurfaces for ultraFAst light STructuring (METAFAST)

The METAFAST project aims to develop a novel class of synthetic nonlinear optical materials, or metamaterials, as a disruptive platform enabling unprecedented ultrafast dynamical control over polarization and wavefront of light. In particular, we will develop ultracompact all-optical modulators capable of faster than ever structuring of the spin and orbital angular momentum (SOAM) of light beams. Such ultrafast optical modulation offers an exceptionally robust method for the encoding of digital information in free space optical links, being also resistant to eavesdropping thanks to topological protection.

More about the project at: https://www.metafast-h2020.eu

More projects on the way

Publications

List of publications

  • Discovering of the L ligand impact on luminescence enhancement of Eu(Dibenzoylmethane)3.Lx complexes employing transient absorption spectroscopy

    Authors: Stanislav S. Stanimirov, Anton A. Trifonov, Ivan C. Buchvarov

    Publication: Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, Volume 258, 2021, 119832 (by Elsevier)

    DOI: 10.1016/j.saa.2021.119832

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  • Ultra-Short Laser Surface Properties Optimization of Biocompatibility Characteristics of 3D Poly-ε-Caprolactone and Hydroxyapatite Composite Scaffolds

    Authors: Albena Daskalova, Emil Filipov, Liliya Angelova, Radostin Stefanov, Dragomir Tatchev, Georgi Avdeev, Lamborghini Sotelo, Silke Christiansen 4,George Sarau, Gerd Leuchs, Ekaterina Iordanova, Ivan Buchvarov

    Abstract:
    The use of laser processing for the creation of diverse morphological patterns onto the surface of polymer scaffolds represents a method for overcoming bacterial biofilm formation and inducing enhanced cellular dynamics. We have investigated the influence of ultra-short laser parameters on 3D-printed poly-ε-caprolactone (PCL) and poly-ε-caprolactone/hydroxyapatite (PCL/HA) scaffolds with the aim of creating submicron geometrical features to improve the matrix biocompatibility properties. Specifically, the present research was focused on monitoring the effect of the laser fluence (F) and the number of applied pulses (N) on the morphological, chemical and mechanical properties of the scaffolds. SEM analysis revealed that the femtosecond laser treatment of the scaffolds led to the formation of two distinct surface geometrical patterns, microchannels and single microprotrusions, without triggering collateral damage to the surrounding zones. We found that the microchannel structures favor the hydrophilicity properties. As demonstrated by the computer tomography results, surface roughness of the modified zones increases compared to the non-modified surface, without influencing the mechanical stability of the 3D matrices. The X-ray diffraction analysis confirmed that the laser structuring of the matrices did not lead to a change in the semi-crystalline phase of the PCL. The combinations of two types of geometrical designs—wood pile and snowflake—with laser-induced morphologies in the form of channels and columns are considered for optimizing the conditions for establishing an ideal scaffold, namely, precise dimensional form, mechanical stability, improved cytocompatibility and antibacterial behavior.

    Keywords: ultra-short laser processing; bone tissue engineering; surface patterns; biodegradable polymers; antibacterial structuring

    DOI: 10.3390/ma14247513

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  • Investigating Potential Effects of Ultra-Short Laser-Textured Porous Poly-ε-Caprolactone Scaffolds on Bacterial Adhesion and Bone Cell Metabolism

    Authors: Emil Filipov, Liliya Angelova, Sanjana Vig, Maria Helena Fernandes, Gerard Moreau, Marie Lasgorceix, Ivan Buchvarov, Albena Daskalova

    Abstract:
    Developing antimicrobial surfaces that combat implant-associated infections while promoting host cell response is a key strategy for improving current therapies for orthopaedic injuries. In this paper, we present the application of ultra-short laser irradiation for patterning the surface of a 3D biodegradable synthetic polymer in order to affect the adhesion and proliferation of bone cells and reject bacterial cells. The surfaces of 3D-printed polycaprolactone (PCL) scaffolds were processed with a femtosecond laser (λ = 800 nm; τ = 130 fs) for the production of patterns resembling microchannels or microprotrusions. MG63 osteoblastic cells, as well as S. aureus and E. coli, were cultured on fs-laser-treated samples. Their attachment, proliferation, and metabolic activity were monitored via colorimetric assays and scanning electron microscopy. The microchannels improved the wettability, stimulating the attachment, spreading, and proliferation of osteoblastic cells. The same topography induced cell-pattern orientation and promoted the expression of alkaline phosphatase in cells growing in an osteogenic medium. The microchannels exerted an inhibitory effect on S. aureus as after 48 h cells appeared shrunk and disrupted. In comparison, E. coli formed an abundant biofilm over both the laser-treated and control samples; however, the film was dense and adhesive on the control PCL but unattached over the microchannels.

    Keywords: ultra-short laser processing; biomaterials; 3D printing; cell adhesion; antibacterial surfaces

    DOI: 10.3390/polym14122382

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  • Single-Step Process for Titanium Surface Micro- and Nano-Structuring and In Situ Silver Nanoparticles Formation by Ultra-Short Laser Patterning

    Authors: Dante Maria Aceti, Emil Filipov, Liliya Angelova, Lamborghini, Tommaso Fontanot, Peyman Yousefi, Silke Christiansen, Gerd Leuchs, Stanislav Stanimirov, Anton Trifonov, Ivan Buchvarov, Albena Daskalova

    Abstract:
    Ultra-short laser (USL)-induced surface structuring combined with nanoparticles synthesis by multiphoton photoreduction represents a novel single-step approach for commercially pure titanium (cp-Ti) surface enhancement. Such a combination leads to the formation of distinct topographical features covered by nanoparticles. The USL processing of cp-Ti in an aqueous solution of silver nitrate (AgNO3) induces the formation of micron-sized spikes surmounted by silver nanoparticles (AgNPs). The proposed approach combines the structuring and oxidation of the Ti surface and the synthesis of AgNPs in a one-step process, without the use of additional chemicals or a complex apparatus. Such a process is easy to implement, versatile and sustainable compared to alternative methodologies capable of obtaining comparable results. Antimicrobial surfaces on medical devices (e.g., surgical tools or implants), for which titanium is widely used, can be realized due to the simultaneous presence of AgNPs and micro/nano-structured surface topography. The processed surfaces were examined by means of a scanning electron microscope (SEM), energy-dispersive X-ray spectroscopy (EDX), atomic force microscopy (AFM) and Raman spectroscopy. The surface morphology and the oxidation, quality and quantity of AgNPs were analyzed in relation to process parameters (laser scanning speed and AgNO3 concentration), as well as the effect of AgNPs on the Raman signal of Titanium oxide.

    Keywords: ultra-short laser processing; titanium; silver nanoparticles; surface patterning; laser ablation; multiphoton photo-reduction

    DOI: 10.3390/ma15134670

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  • Next publications coming soon.

News

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    Creation of scientific capacity for submitting applications for Operational Programs ”SESG” 2014-2020 and Frame Program for scientific research and innovations “Horizon 2020”;

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    Announcement of the organization activities within the territory of Republic of Bulgaria;

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    Creation of contacts with other institutions with similar activities for gathering of knowledge;

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    Creation of contacts with other institutions, including educational, with similar activities for exchange of information for cooperative realization and partnership;

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    Creation of contacts with other institutions with similar activities for exchange of experience and consulting with experts and specialists in the areas of activity of the organization;

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    Participation in conferences, meetings and etc in the area of the scientific research and innovative technologies;

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    Creation of contacts with government and district institutions for helping and solving problems in the area of science and education;

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    Submitting applications for programs and project realization via European Union funds , as well as via other funding organizations and financial institutions.

About

Leading scientists

Leading scientists & united scientific capacity

Contacts

Contact with us

logo „John Atanasoff“ Center for Bio and Nano Photonics (JAC BNP) is a nonprofit organization for public benefit founded by three institutions - Sofia University "St. Kliment Ohridski", the Institute of Bio and Nano Photonics; and the Center for Innovative Technologies at Sofia, Bulgaria.

The vision of the founders is that in an intimate partnership with the Center for Innovative Technology and Sofia University "St. Kliment Ohridski", this new Center will evolve into a national scientific institution with a leadership position at a national and at a global level. At its birth, each major area of scientific research is designed to be coordinated by at least two world leading scholars.

Contacts
Address:
town Sofia 1164
st. James Baucher 5, Faculty of Physics,
Sofia University "St. Kliment Ohridski"
for Assoc. Prof. Ivan Bachvarov

Е-mail: bionano.ph.ja@gmail.com
Phone: +35928161744